Erowid References Database
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Fuller RW, Snoddy HD.
“Long-term effects of 4-chloroamphetamine on brain 5-hydroxyindole metabolism in rats”.
Neuropharmacology. 1974 Jan 17;13(1):85-90.
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Abstract
Four weeks after a single intraperitoneal injection of 4-chloroamphetamine hydrochloride
(0.1 mmol/kg) into rats, brain serotonin and 5-hydroxyindoleacetic acid levels were still
depressed to approximately half the control values, though tryptophan levels in brain were
normal. Serotonin turnover in brain was likewise depressed to about half of the control rate as measured by (a) the rate of serotonin accumulation after monoamine oxidase inhibition and (b) the rate of 5-hydroxyindoleacetic acid accumulation after probenecid administration to block its
efflux. Despite this decreased turnover rate, the capacity of the brain to synthesize 5-hydroxyindoles, as indicated by the increases in serotonin and 5-hydroxyindoleacetic acid after the injection of various doses of L-tryptophan was not altered.
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