Erowid.org: Erowid Reference 842 : MDMA: further evidence that its action in the medial prefrontal cortex is mediated by the serotonergic system : Pan HS, Wang RY

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Pan HS, Wang RY. “MDMA: further evidence that its action in the medial prefrontal cortex is mediated by the serotonergic system”. Brain Res. 1991;539(2):332-6. <a name="ref">Pan HS, Wang RY.</a> <a href="/references/842">"MDMA: further evidence that its action in the medial prefrontal cortex is mediated by the serotonergic system"</a> <i>Brain Res</i>. 1991;539(2):332-6.
Text Abstract (this page) Full Text - English (private) Show Articles by Pan HS Wang RY Article IDs Erowid RefID: 842 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Systemically administered (+/-)-MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') suppressed the firing rates of the majority of neurons in the medial prefrontal cortex (mPFc). The responses of mPFc cells to (+/-)-MDMA is mimicked by (+)-MDMA but not (-)-MDMA. Furthermore, pretreatment with fluoxetine (a specific 5-HT uptake blocker) but not GBR 12909 (a specific dopamine uptake blocker) prevented the suppressant action of MDMA. These data support the notion that the 5-HT system mediates (+/-)-MDMA's action.
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