Erowid References Database
Sard H, Kumaran G, Morency C, Roth BL, Toth BA, He P, Shuster L.
“SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist”.
Bioorg Med Chem Lett. 2005 Oct 12;15(20):4555-9.
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Abstract
An SAR study of psilocybin and psilocin derivatives reveals that 1-methylpsilocin is a selective agonist at the h5-HT(2C) receptor. The corresponding phosphate derivative, 1-methylpsilocybin, shows efficacy in an animal model for obsessive-compulsive disorder, as does 4-fluoro-N,N-dimethyltryptamine. These results suggest a new area for development of novel 5-HT(2C) agonists with applications for drug discovery.
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