Erowid.org: Erowid Reference 856 : Ring-substituted amphetamine interactions with neurotransmitter receptor binding sites in human cortex : Pierce PA, Peroutka SJ

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Pierce PA, Peroutka SJ. “Ring-substituted amphetamine interactions with neurotransmitter receptor binding sites in human cortex”. Neurosci Lett. 1988;95(1-3):208-12. <a name="ref">Pierce PA, Peroutka SJ.</a> <a href="/references/856">"Ring-substituted amphetamine interactions with neurotransmitter receptor binding sites in human cortex"</a> <i>Neurosci Lett</i>. 1988;95(1-3):208-12.
Text Abstract (this page) Full Text - English (private) Show Articles by Pierce PA Peroutka SJ Article IDs Erowid RefID: 856 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract The binding affinities of 3 ring-substituted amphetamine compounds were determined at 9 neurotransmitter binding sites in human cortex. (+/-)-3,4-Methylenedioxyamphetamine (MDA), (+/-)-3,4-methylenedioxyethamphetamine (MDE), and (+/-)-3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') all display highest affinity (approximately 1 microM) for the recently identified 'DOB binding site' labeled by [77Br]R(-)4-bromo-2,5-dimethoxyphenylisopropylamine [( 77Br]R(-)DOB). MDA displays moderate affinity (4-5 microM) for the 5-hydroxytryptamine1A (5-HT1A), 5-HT1D, and alpha 2-adrenergic sites in human cortex. MDE and MDMA display lower affinity or are inactive at all other sites tested in the present study. These observations are discussed in relation to the novel psychoactive effects of the ring-substituted amphetamines.
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