Erowid.org: Erowid Reference 886 : Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') : Ricaurte GA, McCann UD, Szabo Z, Scheffel U

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Ricaurte GA, McCann UD, Szabo Z, Scheffel U. “Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')”. Toxicol Lett. 2000;112-113:143-6. <a name="ref">Ricaurte GA, McCann UD, Szabo Z, Scheffel U.</a> <a href="/references/886">"Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')"</a> <i>Toxicol Lett</i>. 2000;112-113:143-6.
Text Abstract (this page) Full Text - English (private) Show Articles by Ricaurte GA McCann UD Szabo Z Scheffel U Article IDs Erowid RefID: 886 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract The recreational drug, (+/-)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [11C]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [11C]McN-5652 binding, with decreases in [11C]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity.
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