Erowid References Database
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Seiden LS, Kleven MS.
“Methamphetamine and related drugs: toxicity and resulting behavioral changes in response to pharmacological probes”.
NIDA Res Monogr. 1989;94:146-60.
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Abstract
Some substituted phenethylamines are toxic to certain neurons in the brain. In view of this neurotoxicity, we will review some data relevant to this process. First, we will review data showing that methamphetamine (METH), a prototypic psychomotor stimulant, which has been widely used for nonmedical purposes at doses often a good deal higher than therapeutic doses, is neurotoxic to dopamine(DA) and serotonin (5-hydroxytryptamine (5-HT)) systems. Second, we will examine the evidence that other substituted phenethylamines are also neurotoxic to certain transmitter systems. Last, we will examine the behavioral and pharmacological consequences of neurotoxicity that result from exposure to some of these amphetamine-related drugs.
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