Erowid.org: Erowid Reference 972 : Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan : Sprague JE, Huang X, Kanthasamy A, Nichols DE

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Sprague JE, Huang X, Kanthasamy A, Nichols DE. “Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan”. Life Sci. 1994;55(15):1193-8. <a name="ref">Sprague JE, Huang X, Kanthasamy A, Nichols DE.</a> <a href="/references/972">"Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan"</a> <i>Life Sci</i>. 1994;55(15):1193-8.
Text Abstract (this page) Full Text - English (private) Show Articles by Sprague JE Huang X Kanthasamy A Nichols DE Article IDs Erowid RefID: 972 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) induced serotonergic neurotoxicity as measured by [3H]-paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 5-HIAA levels were also indicative of the protective effects of TRP and 5-HTP. These results suggest that depletion of 5-HT stores is important for MDMA-induced neurotoxicity. The possible significance of this 5-HT depletion in MDMA-induced serotonergic terminal degeneration is also discussed.
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