Erowid References Database
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Draskoci M.
“Assay of lysergic acid diethylamide and its passage from blood into the perfused cerebral ventricles.”.
Brit.J.Pharmacol.. 1960;15:29.
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Abstract
The isolated rat uterus was stimulated by LSD 2 x 10-8. LSD 10-9-10-10 did not stimulate the uterus but potentiated the stimulating effect of acetylcholine. This potentiating effect was used to assay LSD in the blood plasma of 6 cats (barbiturate anesthesia) continuously receiving LSD (10 mcg/kg/min) by i.v. infusion and in the perfusate of their cerebral ventricles continuously perfused, from a cannula in a lateral ventricle to a cannula in the aqueduct or in the cisterna, with a physiological solution not containing LSD. .
RESULTS: LSD plasma level. In the 5 cats receiving LSD for 2 hours the plasma contained 1-2 mcg/ml LSD after 1 or 2 hours. In the one cat receiving LSD during 4 hours, the level was 4.5-5.0 mcg/ml after 2, 3 and 4 hours. . LSD output from cerebral ventricles varied between 0.0004 and 0.0019 mcg/min. . Outputs from the aqueduct [which belongs to the system] of cerebral ventricles and in the cisterna which forms part of the subarachnoidal space were about equal in the same cat. Thus probably all the LSD in the cisternal effluent had entered the perfusion fluid during its passage through the lateral and third ventricles. It is doubtful whether LSD can also pass directly from the blood into the subarachnoidal space. . Comment: Regarding concentration of LSD in the blood, brain and cerebrospinal fluid of cats and monkeys, see 297.
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