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Schaefer A, Komlos M, Seregi A.
“Lipid Peroxidation As The Cause Of The Ascorbic Acid Induced Decrease Of Adenosine Triphosphatase Activities Of Rat Brain Microsomes And Its Inhibition By Biogentc Amines And Psychotropic Drugs”.
Biochem. Pharmacol.. 1975;24:1781-1786.
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Abstract
The inhibitory effect of ascorbic acid on microsomal Na+' K+-ATPase and Mg24-ATPase activities of rat brain and the ability of several mediator substances and of many drugs acting on the nervous system to antagonize this inhibition was studied. The maximal effect of ascorbic acid on ATPase activities was completely antagonized by catecholamines, apomorphine. oxyperfine, reserpine, tetrabenazine, phenothiazines (chlorpromazine and promethazine) and yohimbine at a concentration of 10-4M or below. Apomorphine proved to be the most effective compound, fully antagonizing the effect of ascorbic acid at a concentration of 10-6M. A partial inhibition of the effect of ascorbic acid was induced by 10-4M serotonin, desipramine, imipramine and LSD. During the incubation of the microsomes for ATPase activity determinations in the presence of ascorbic acid, a significant amount of lipid peroxide was formed. Compounds which antagonized the effect of ascorbic 7 acid on the ATPase activities inhibited at the same concentrations the lipid peroxide formation. The well-known inhibitors of lipid peroxidation eliminated the effect of ascorbic acid on the ATPase activities. It has been established that the inhibition of ATPase activities by ascorbic acid is a consequence
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