Erowid References Database
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Boullin DJ, Glenton PAM.
“Characterization of Receptors Mediating 5-Hydroxytryptamine and Catecholamine-Induced Platelet Aggregation, Assessed by the Actions of a- and p-Blockers, Butyrophenones, 5-HT Antagonists and Chlorpromazine”.
Brit.J.Pharmacol.. 1978;62(4):537 -42.
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Abstract
The effects of potential antagonists on human platelet aggre gation induced by 5-hydroxytryptamine (5-HT), noradrenaline (N) dopamine (D) and N-dimethyl-dopamine (MD) were studied in vitro. Method The inhibitory effects of methysergide, lysergic acid diethyl amide (LSD) (both Sandoz), BW 501C67 (Wellcome), haloperidol, spiroperidol (both Janssen), phentolamine (CIBA-Geigy), (+) propranolol, (-)-propranolol (both ICI) and chlorpromazine on human platelet aggregation produced by 5-HT (20 )lmol/l), NA (20 umol/l), D 50 and 200 mol/l) (all Sigma-chem.) and MD (20 umol/l) were measured densitometrically. IC50s (antagonist concentration producing 50 0nhibition) values were calculated. Methysergide, LSD, BW 501C67 and spiroperidol (all 1 nmol 1 mcmol/l) strongly inhibited platelet aggregation induced by 5-HT Chlorpromazine (0.1 - 10 mcmol/1) had a much weaker effect. Phe tolamine, haloperidol, (+)-propranolol and (-)-propranolol (all> 10 mcmol/l) were the least potent antagonists. Phentolamine (1 mol/l) was the most effective inhibitor of aggregation induced by NA, MD and DA. All other drugs were effective only in higher concentrations (10 - 200 mcmol/l). There are 2 distinct populations of receptors mediating platelet aggregation. These are probably 5-HT receptors of low - structural specificity and catecholamine a-adrenoreceptors.
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