Erowid References Database
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Henriksson BG, Johansson JO, Jarbe TUC.
“Delta 9 Tetrahydrocannabinol Produced Discrimination In Pigeons”.
Pharm Biochem Behav. 1975;3(5):771-774.
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Abstract
IN AN OPERANT SITUATION PIGEONS LEARNED TO PECK ONE RESPONSE KEY 90 MIN AFTER AN INJECTION OF 0.25 MG/KG DELTA9 TETRAHYDROCANNABINOL (DELTA9 THC) AND ANOTHER KEY WHEN TRAINED NONDRUGGED. WHEN TESTED WITH DOSES OF DELTA9 THC LOWER THAN THE TRAINING DOSE THE BIRDS DISCRIMINATED 0.20 MG/KG OF THE DRUG FROM THE NONDRUGGED STATE BUT NOT 0.15 MG/KG OR LOWER DOSES. THE ANIMALS WERE ABLE TO DISCRIMINATE THE DRUG STATE FROM THE NONDRUGGED 180 MIN BUT MOT 360 MIN AFTER THE INJECTION. AT A SHORTER INTERVAL (45 MIN) BOTH DRUG AND NONDRUG RESPONDING APPEARED. CANNABINOL AND CANNABIDIOL (4.0-8.0 MG/KG) DID NOT ELICT ANY DRUG RESPONSES, NOR DID PENTOBARBITAL, DITRAN OR AMPHETAMINE. TESTS WITH LSD RESULTED IN BOTH DRUG AND NONDRUG RESPONDING. WHEN ADMINISTERING NONCANNABINOL DRUGS IN COMBINATION WITH DELTA9 THE 015 MO/KG THE BIRDS RESPONDED AT THE KEY ASSOCIATED WITH THE DRUG STATE, SUGGESTING INTERACTIONAL EFFECTS.
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